In this study, we demonstrate that an aromatic oligoamide sequence assembles into a trimeric helix-turn-helix architecture with a disulfide linkage, and upon cleavage of this linkage, it reconstructs into an antiparallel double helix. The antiparallel double helix is accessible to encapsulate a diacid guest within its cavity, forming a 2:1 host–guest complex. In contrast, hydrogen-bonding interactions between the trimeric-assembled structure and guests induce a conformational shift in the trimeric helix, resulting in a cross-shaped double-helix complex at a 2:2 host–guest ratio. Interconversions between the trimeric helix and the antiparallel double helix, along with their respective host–guest complexes, can be initiated through thiol/disulfide redox-mediated regulation.

中文翻译：

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先进结构中芳香族低酰胺折叠体的氧化还原调节和客体驱动转化

在这项研究中，我们证明芳香族寡酰胺序列组装成具有二硫键的三聚体螺旋-转角-螺旋结构，并且在该连接断裂后，它重建成反平行双螺旋。反平行双螺旋可将二酸客体封装在其空腔内，形成 2:1 的主客体复合物。相比之下，三聚体组装结构和客体之间的氢键相互作用会引起三聚体螺旋的构象转变，从而形成主客体比例为 2:2 的十字形双螺旋复合物。三聚螺旋和反向平行双螺旋之间的相互转化，以及它们各自的主客体复合物，可以通过硫醇/二硫键氧化还原介导的调节来启动。